“The Tao that can be told is not the eternal Tao. The biosphere that can be described is not the biosphere that will become.”
"What’s the largest unsolved problem in complexity science? Getting beyond its utter dependence upon mathematics."
'Life is a nonequilibrium, self-reproducing chemical reaction system that achieves: i. Collective autocatalysis, ii. Constraint Closure, iii. Spatial Closure.
"In Critique of Judgment, 1793, Kant wrote: 'an organised being has the property that the parts exist for and by means of the whole.' He was trying to find a notion of natural purpose. Every living organism is a Kantian whole. You have a heart and a liver and a kidney and a spleen. They exist because they’re part of you, and you exist because of them. Once you’ve got the notion of a Kantian whole—of parts and whole—you can talk about the function of a part, non-reductively and non-circularly
Inside the environment of the cell, viruses are Kantian Wholes that reproduce. The Parts of the virus, in the context of the cell, create multiple copies of the Parts of the virus that self-assemble into the mature virus Whole. It is of interest that a definition of life including that of a Kantian Whole classifies viruses as alive. Kantian Wholes are a special class of dynamical physical systems. A crystal is not a Kantian whole. The atoms of the crystal can exist without being parts of the crystal. A brick is not a Kantian Whole. A cell is a Kantian Whole."
'It is of the deepest importance that all living cells achieve constraint closure. Cells construct the very boundary conditions on the release of energy that constructs the very same boundary conditions. Cells construct themselves. Computers and locomotives do not construct themselves. Reproducing cells are fundamentally not von Neumann’s self-reproducing automata, (20). These are based on a “Universal Constructor.” To construct anything specific, the Universal Constructor requires specific “Instructions.” These are encoded in a physical system placed inside the Universal Constructor. The physically embodied instructions play dual roles: They are used to construct a copy of the Universal Constructor into which a physical copy of the physical Instructions is constructed and then inserted. The dual roles of the physical Instructions constitute precisely the distinction between software and hardware. In sharpest contrast, a living cell, via catalytic and constraint closure, constructs specifically itself. A cell is not a universal constructor requiring separate Instructions.'
"The function of your heart is that subset of its causal properties that sustains you. Your heart pumps blood. But your heart also makes heart sounds, and it jiggles water in your cardiac sac. Your heart makes indefinitely many different sets of causal properties. Unlike mathematics, the actual behaviour is physical, not symbolic. Mathematics misses the physicality."
Darwinian Exaptations or Evolutionary Co-Options as defined by Gould and Vrba: "(1) A character, previously shaped by natural selection for a particular function (an adaptation), is coopted for a new use—cooptation. (2) A character whose origin cannot be ascribed to the direct action of natural selection (a nonaptation), is coopted for a current use—cooptation."
"Here’s a Kantian whole. It’s got a bunch of parts. Each part has a very large number—I will say indefinitely many—subsets of causal features. Any one of them could become of use. But from the use of a heart to pump blood, you cannot deduce that jiggling water in the pericardial sac might be of survival value. There’s no deductive relationship between the different uses of parts. And the word “use” is not in physics, but it is in biology. The implication is open biological evolution is real, and it’s real because parts come to have and have used different functions. So that underlying open evolution is not deducible.
So uses of things have the following three properties: they can’t be put into one-to-one correspondence with the integers; use of things is just a nominal scale; there’s no ordering relationship; you cannot deduce one use from another. Therefore, the indefinite is fundamental."
"The indefinite is things with the property that they cannot be listed, cannot be ordered relative to one another, and cannot be deduced from one another. The definition is instantiated by the Darwinian pre-adaptations. This opposes Plato’s forms, the eternal realm, and the fundamental notion—which is central to Newton—that all the possibilities already exist. And that’s Newton’s pre-stated fixed-state space. At the pre-stated fixed-state space of quantum mechanics, biological evolution creates new possibilities. They come into existence. Tigers came into existence. A tearing head. And that’s why biological evolution is open-ended. But it also means the evolution of the biosphere is an undeducible propagated construction, not a tale of deduction. There is no theory of everything."
"We in the West have looked for 2,500 or 2,400 years on the basis of Plato’s Logos: the world is understandable, which is his internal realm, where all the possibilities already exist. The possibilities already exist—again, as Newton’s pre-stated state space. It’s the state space bit of quantum mechanics. It’s the pre-statement of probability theory. All the possibilities already exist; therefore you can calculate a probability. It’s the same thing thinking of statistical mechanics: all possibilities already exist. Essentially all of physics, all of complexity theory, is in the formal world. And essentially it’s in Plato’s world.
But the evolving biosphere isn’t."
"-There are new possibilities. When the tiger and the gazelle evolved, tigers could eat gazelles, and the possibility that a tiger will catch a gazelle and get dinner is real. Three billion years ago, there wasn’t the possibility that the tiger exists. The possibility itself came into being. And it does so because Darwinian pre-adaptations really are new possibilities. Once a swim bladder exists, for example—it evolved because it was good at being a swim bladder, namely neutral buoyancy in the water column—but watch: once it’s true that there is a swim bladder, is it now possible that a worm could evolve to live only in swim bladders?
-Sure.
-Before there was a swim bladder, was that possible?
-No.
-New possibilities come to exist all the time in the evolving biosphere, and that’s outside of the purview of physics. So life depends on physics, but can’t be reduced to it.
And if that’s right, then, beloved, there is no theory of everything—if you want the theory of everything to include an evolving biosphere."
"Technological evolution is the same thing. You cannot get a crossbow until you’ve got a bow. If you’ve got a bow, it is not hard to think about a crossbow. So technological evolution is doing the same thing. It is innovating based on what’s around, typically for a new use. And if it’s new, we see if it’s patentable. It’s not invented.
Did you ever see this wonderful series of James Burke called Connections? It’s about the evolution of technology. It’s wonderful. One of them is about the evolution of the carburetor. I think it’s the carburetor from a Persian biologist’s coarse perfume. Or the cannon evolved from a church bell. Think of the shape of the bell, squeeze it in, and it becomes a cannon. That’s “cannon” for “invented.” Most inventions are pre-adaptations—Darwinian exaptations—of things that already exist. There’s not a pre-existing space of all the possibilities."
"If we cannot say what will next become, we cannot pre-state it like the now. We don’t know the sample size of the process, so we can’t define probability, so we can’t define “random,” so we can’t assess risk for you true capitalists. You kind of know that.
And now I get something fundamentally cultural to it. It means Plato and Newton gave us a machine. The world is a machine. It’s a clockwork. But a machine has a property that we can master it, and we have dominion, which is what Roger Bacon told us.
In fact, we cannot reason about what is going to become. The response has to be participation, not dominion. So it got into some kind of cultural transformation, there is something about humanity and participation and wisdom—not dominion power.
It’s this stuff glimmering in me, and I don’t know."
















